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Invisible endometriosis
Endometriosis and the desire for pregnancy
In episode 7, Carole Minker explains why endometriosis can impact fertility, how oxidative stress and inflammation disrupt implantation, and what natural levers to activate to optimize your chances.
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Summary
🔊 This program is an information program by a trained professional. This is generic advice and is not a personalized diagnosis. In all cases, we recommend that you be followed by a gynecologist and/or a midwife for individualized follow-up.
What you will learn in this episode
In this episode, Carole Minker explains the link between endometriosis and fertility. A real link, but not a fatality. You will understand why oxidative stress, inflammation, and hormonal imbalances can complicate conception, what happens at the time of implantation, and what concrete actions to take to optimize fertility, with or without ART.
The numbers to know, and to put into perspective
It is estimated that 30-40% of women with endometriosis suffer from infertility. It also means that 60 to 70% of affected women can conceive, sometimes even naturally, without even knowing that they have endometriosis. Just because you have endometriosis doesn't mean you can't have children. And just because we're going to PMA doesn't mean there's nothing else we can do to optimize.
💡 Key figures
30-40% of women with endometriosis suffer from infertility. This means that 60 to 70% of them can conceive, sometimes without even knowing they have the disease.
Source: Pasteur Institute, October 2024
Why fertility may be impacted
Oxidative stress and inflammation in the pelvic environment can alter sperm motility, i.e. their ability to move.
Inefficient sperm cells in an inflammatory environment are already a first obstacle even before fertilization.
Oxidative stress also attacks oocytes. And the endometrium itself, in affected women, has particular characteristics compared to a healthy endometrium, which can affect uterine receptivity.
In addition to these mechanisms, resistance to progesterone, a hormone essential for implantation and the maintenance of a pregnancy, can be added.
Nidation: the most delicate stage
When an embryo is formed, it descends to the endometrium to be implanted. However, an embryo is at least 50% foreign to the maternal organism. PIn order for it to set up, the immune system must activate very fine tolerance mechanisms. In an environment marked by chronic inflammation, an imbalance in the endometrial microbiota, and immune dysfunction, this process can be disrupted.
This is often the most delicate stage in the fertility journey with endometriosis.
An important message to remember
Some doctors still say that having a baby cures endometriosis. It's not true. Many women experience a respite during pregnancy, which is likely related to hormonal and immune changes in this condition. But endometriosis is a chronic condition. It does not go away with pregnancy.
🔎 Useful definitions
Nidation : process by which the embryo is implanted in the uterine mucosa. For it to be successful, the endometrium must be receptive and the immune system must tolerate this embryo, which is genetically foreign to the maternal organism.
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Oxidative stress : imbalance between free radicals and antioxidants in the body. It can alter the quality of oocytes, sperm, and the uterine environment, complicating conception and implantation.
🎯 Actions concrètes
- Support the microbiota: as seen in the previous episode, a balanced intestinal microbiota directly influences the uterine environment and endometrial receptivity.
- Check the main deficiencies before planning a pregnancy:
- Magnesium, vitamin D, and omega-3 are the three most common deficiencies in the population.
- Vitamin D cannot be supplemented blindly: a blood test allows you to know where you are starting from and to adapt the dose.
- Work on methylation if necessary. Vitamins B9 and B12 play an important role in both fertility and endometriosis.
- In case of deficiencies or methylation problems identified, correcting them is part of optimization.
- Reduce inflammation and endocrine disruptors.
- These are the two levers that, by being silent, allow fertility to increase,
- Adopt an anti-inflammatory diet,
- remove industrial products and cosmetics loaded with endocrine disruptors.
- Do not wait to optimize, even in PMA.
- Entering into an ART protocol is not a reason to do nothing else. On the contrary, preparing the ground before oocyte retrieval and supporting the uterine environment can make a real difference.
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Summary
🔊 This program is an information program by a trained professional. This is generic advice and is not a personalized diagnosis. In all cases, we recommend that you be followed by a gynecologist and/or a midwife for individualized follow-up.
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⭐ La série Invisible endométriose est possible grâce à la participation de Norsan. L'épisode Bonus leur est dédié, et vous en apprendrez plus sur les Oméga 3 dans l'épisode 9. Norsan, entreprise spécialiste en production d'Oméga 3 depuis 2013 sont le plus grand distributeurs d'Oméga 3 en pharmacie car leur Oméga 3 naturels et de haute qualité font partie aujourd'hui des meilleurs Oméga 3 disponibles sur le marché.
What you will learn in this episode
In this episode, Carole Minker explains the link between endometriosis and fertility. A real link, but not a fatality. You will understand why oxidative stress, inflammation, and hormonal imbalances can complicate conception, what happens at the time of implantation, and what concrete actions to take to optimize fertility, with or without ART.
The numbers to know, and to put into perspective
It is estimated that 30-40% of women with endometriosis suffer from infertility. It also means that 60 to 70% of affected women can conceive, sometimes even naturally, without even knowing that they have endometriosis. Just because you have endometriosis doesn't mean you can't have children. And just because we're going to PMA doesn't mean there's nothing else we can do to optimize.
💡 Key figures
30-40% of women with endometriosis suffer from infertility. This means that 60 to 70% of them can conceive, sometimes without even knowing they have the disease.
Source: Pasteur Institute, October 2024
Why fertility may be impacted
Oxidative stress and inflammation in the pelvic environment can alter sperm motility, i.e. their ability to move.
Inefficient sperm cells in an inflammatory environment are already a first obstacle even before fertilization.
Oxidative stress also attacks oocytes. And the endometrium itself, in affected women, has particular characteristics compared to a healthy endometrium, which can affect uterine receptivity.
In addition to these mechanisms, resistance to progesterone, a hormone essential for implantation and the maintenance of a pregnancy, can be added.
Nidation: the most delicate stage
When an embryo is formed, it descends to the endometrium to be implanted. However, an embryo is at least 50% foreign to the maternal organism. PIn order for it to set up, the immune system must activate very fine tolerance mechanisms. In an environment marked by chronic inflammation, an imbalance in the endometrial microbiota, and immune dysfunction, this process can be disrupted.
This is often the most delicate stage in the fertility journey with endometriosis.
An important message to remember
Some doctors still say that having a baby cures endometriosis. It's not true. Many women experience a respite during pregnancy, which is likely related to hormonal and immune changes in this condition. But endometriosis is a chronic condition. It does not go away with pregnancy.
🎯 Concrete actions
- Support the microbiota: as seen in the previous episode, a balanced intestinal microbiota directly influences the uterine environment and endometrial receptivity.
- Check the main deficiencies before planning a pregnancy:
- Magnesium, vitamin D, and omega-3 are the three most common deficiencies in the population.
- Vitamin D cannot be supplemented blindly: a blood test allows you to know where you are starting from and to adapt the dose.
- Work on methylation if necessary. Vitamins B9 and B12 play an important role in both fertility and endometriosis.
- In case of deficiencies or methylation problems identified, correcting them is part of optimization.
- Reduce inflammation and endocrine disruptors.
- These are the two levers that, by being silent, allow fertility to increase,
- Adopt an anti-inflammatory diet,
- remove industrial products and cosmetics loaded with endocrine disruptors.
- Do not wait to optimize, even in PMA.
- Entering into an ART protocol is not a reason to do nothing else. On the contrary, preparing the ground before oocyte retrieval and supporting the uterine environment can make a real difference.
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