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Invisible endometriosis
Where does endometriosis come from? Genetics and risk factors
In episode 2, Carole Minker explains the origins of endometriosis: inheritance, epigenetics, immunity, and lifestyle, and why this disease is multifaceted.
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Summary
🔊 This program is an information program by a trained professional. This is generic advice and is not a personalized diagnosis. In all cases, we recommend that you be followed by a gynecologist and/or a midwife for individualized follow-up.
What you will learn in this episode
In this episode, Carole Minker explains where endometriosis comes from. A multifaceted disease, whose origins combine genetics, epigenetics, immune dysfunction and environmental factors. You will understand why there is no single cause, how the environment can modulate the expression of your genes, and where to start concretely to act on your health on a daily basis.
Endometriosis is a multifaceted disease. There is no single cause, but a set of factors that can be combined differently for each woman.
Heredity and epigenetics
There are genetic risk factors. In some families, from generation to generation, typical symptoms of endometriosis are observed, even without a formal diagnosis in previous generations. But having a predisposing gene does not mean that the disease will necessarily develop.
That's where epigenetics comes in. Carole uses a simple image: it's like a lamp. You don't choose which lamp you have, but you can choose to turn it on or off. Food, stress, endocrine disruptors, pollution, certain medicinal plants, everything around us can modulate the expression of our genes. It is a part that can be acted on.
💡 Key figures
25% of women with endometriosis have no pain. Some only discover their diagnosis at the time of a planned pregnancy.
The role of the immune system
When an endometriosis cell arrives in a place where it shouldn't be, the immune system should normally recognize and eliminate it. If it persists, it is because this mechanism did not work properly. This immune dysfunction plays a role in the development and maintenance of the disease. And it is also the immune system that generates inflammation, and endometriotic lesions feed on inflammation.
The other factors
There are also obstetric factors, environmental factors, and potentially the involvement of certain stem cells and microbiota, which Carole will discuss in a dedicated episode. The list is long and research continues to advance on these topics.
Where do you start?
Faced with this complexity, Carole recommends starting by identifying the urgency of the moment. For some, it will be pain. For others, infertility or fatigue. You can't change everything at once: you move forward in stages, starting with what is most pressing.
A solid foundation is based on what Carole calls the three S's: sport, sleep, and stress.
Without working on these three pillars, no complementary approach will be able to have its full effect. No need to do 50 hours of sport per week: the objective is a gentle and regular practice, adequate sleep and attention to what generates stress on a daily basis.
Carole also recalls that 25% of women with endometriosis have no pain. Some only discover their diagnosis at the time of a planned pregnancy. And many went under the radar because they were told that it was normal to have pain during periods.
🔎 Useful definitions
Epigenetics : set of mechanisms that modulate gene expression without changing their structure. Food, stress, endocrine disruptors, or certain plants can activate or deactivate certain genes.
Genetic polymorphism : a variation in the sequence of a gene, also called mutation. Certain polymorphisms may be involved in the risk of developing endometriosis and may be investigated during in-depth investigations.
🎯 Actions concrètes
- Continue the daily follow-up log. Note your symptoms, but also your triggers: diet, stress, sleep quality, rhythm changes. Identify what makes your condition better as well as what makes it worse.
- Work on the three S. Incorporate gentle and regular physical activity, ensure the quality of your sleep, and identify your main sources of stress to start reducing them. It is the foundation upon which everything else can be based.
- Questioning your family line. If possible and the subject is not taboo, ask questions to the women in your family, on the maternal and paternal sides: intense period pain, difficulty getting pregnant, bleeding periods.
- Even without a formal diagnosis, this information can be valuable.
- Identify your current priority. Pain, fatigue, infertility, mental fog.
- Start with what impacts your daily life the most today, without trying to solve everything at once.
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Summary
🔊 This program is an information program by a trained professional. This is generic advice and is not a personalized diagnosis. In all cases, we recommend that you be followed by a gynecologist and/or a midwife for individualized follow-up.
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⭐ La série Invisible endométriose est possible grâce à la participation de Norsan. L'épisode Bonus leur est dédié, et vous en apprendrez plus sur les Oméga 3 dans l'épisode 9. Norsan, entreprise spécialiste en production d'Oméga 3 depuis 2013 sont le plus grand distributeurs d'Oméga 3 en pharmacie car leur Oméga 3 naturels et de haute qualité font partie aujourd'hui des meilleurs Oméga 3 disponibles sur le marché.
What you will learn in this episode
In this episode, Carole Minker explains where endometriosis comes from. A multifaceted disease, whose origins combine genetics, epigenetics, immune dysfunction and environmental factors. You will understand why there is no single cause, how the environment can modulate the expression of your genes, and where to start concretely to act on your health on a daily basis.
Endometriosis is a multifaceted disease. There is no single cause, but a set of factors that can be combined differently for each woman.
Heredity and epigenetics
There are genetic risk factors. In some families, from generation to generation, typical symptoms of endometriosis are observed, even without a formal diagnosis in previous generations. But having a predisposing gene does not mean that the disease will necessarily develop.
That's where epigenetics comes in. Carole uses a simple image: it's like a lamp. You don't choose which lamp you have, but you can choose to turn it on or off. Food, stress, endocrine disruptors, pollution, certain medicinal plants, everything around us can modulate the expression of our genes. It is a part that can be acted on.
💡 Key figures
25% of women with endometriosis have no pain. Some only discover their diagnosis at the time of a planned pregnancy.
The role of the immune system
When an endometriosis cell arrives in a place where it shouldn't be, the immune system should normally recognize and eliminate it. If it persists, it is because this mechanism did not work properly. This immune dysfunction plays a role in the development and maintenance of the disease. And it is also the immune system that generates inflammation, and endometriotic lesions feed on inflammation.
The other factors
There are also obstetric factors, environmental factors, and potentially the involvement of certain stem cells and microbiota, which Carole will discuss in a dedicated episode. The list is long and research continues to advance on these topics.
Where do you start?
Faced with this complexity, Carole recommends starting by identifying the urgency of the moment. For some, it will be pain. For others, infertility or fatigue. You can't change everything at once: you move forward in stages, starting with what is most pressing.
A solid foundation is based on what Carole calls the three S's: sport, sleep, and stress.
Without working on these three pillars, no complementary approach will be able to have its full effect. No need to do 50 hours of sport per week: the objective is a gentle and regular practice, adequate sleep and attention to what generates stress on a daily basis.
Carole also recalls that 25% of women with endometriosis have no pain. Some only discover their diagnosis at the time of a planned pregnancy. And many went under the radar because they were told that it was normal to have pain during periods.
🎯 Concrete actions
- Continue the daily follow-up log. Note your symptoms, but also your triggers: diet, stress, sleep quality, rhythm changes. Identify what makes your condition better as well as what makes it worse.
- Work on the three S. Incorporate gentle and regular physical activity, ensure the quality of your sleep, and identify your main sources of stress to start reducing them. It is the foundation upon which everything else can be based.
- Questioning your family line. If possible and the subject is not taboo, ask questions to the women in your family, on the maternal and paternal sides: intense period pain, difficulty getting pregnant, bleeding periods.
- Even without a formal diagnosis, this information can be valuable.
- Identify your current priority. Pain, fatigue, infertility, mental fog.
- Start with what impacts your daily life the most today, without trying to solve everything at once.
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