Better Eggs
Oxidative stress and inflammation: the plagues of health and oocyte quality
In episode 5, Carole explains to us the process of chronic inflammation and oxidative stress, and how to improve them for better health.
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🔊 This program is an information program by a trained professional. This is generic advice and is not a personalized diagnosis. In all cases, we recommend that you be followed by a gynecologist and/or a midwife for individualized follow-up.
What you will learn in this episode
Oxidative stress and inflammation: what you need to know to manage them
- What is oxidative stress and the difference between oxidation and anti-oxidants
- How pollution, tobacco, stress, food... maintain chronic low-grade inflammation
- How oxidative stress and inflammation can damage cells, hormones, and oocyte quality
- What tests can explore inflammation and oxidative stress (highly sensitive CRP, specialized tests)
- Concrete daily levers: diet, lifestyle, targeted supplements, microbiota
Oxidative stress: what are we talking about?
Carole compares oxidative stress to a rusty nail: in the body, it is an imbalance between the production of free radicals and our anti-oxidant defenses.
A certain level of free radicals is normal and useful, but when they are produced in excess (tobacco, pollution, stress, poor diet...), they attack the lipids and proteins in our cells and end up damaging them.
- Ce oxidative stress ultimately promotes chronic low-grade inflammation, that stays “on” all the time instead of being punctual;
- In the field of fertility, it is associated with poorer oocyte quality, to more damage to the follicle and to poorer fertilization rates.
💡 Key figures
According to a study carried out in Denmark by the Fertily Department, women with mild chronic inflammation have approximately 10 to 20% less chance that the treatment works compared to those who don't.
Chronic inflammation: who is affected?
Carole recalls that you can sometimes “feel” that something is wrong, without it being measurable right away, but some situations are clearly at risk:
- Chronic inflammatory diseases (Crohn's disease, ulcerative colitis, rheumatoid arthritis, autoimmune diseases...)
- Persistent infections or viruses, lingering inflammations, pain or chronic symptoms
- And in a quieter way, low-grade inflammation linked to lifestyle (overweight, sedentary lifestyle, ultra-processed food, chronic stress...)
To objectify it:
- La Highly sensitive CRP is a simple test that makes it possible to assess a discreet inflammation and to monitor the effect of the actions implemented over time.
- For the oxidative stress, there are more comprehensive assessments, often in the form of non-reimbursed “packs”, which look at both the level of free radicals and certain key nutrients (for example selenium, which is also important for the thyroid).
Carole specifies that we do not do these assessments “to scare yourself” on a person in good shape without any particular problems: they are especially useful when there is a known inflammatory terrain or a baby project that is not progressing despite an initial assessment already well explored.
Act on the basics first: lifestyle
Before talking about complements, Carole comes back to the foundations:
- Limiting what feeds oxidative stress: tobacco, pollution, excess alcohol, lack of sleep, diet low in vegetables and fruits.
- Increase the natural intake of anti-oxidants via the plate: various vegetables, fruits, good oils, oilseeds, spices, etc.
- Move regularly, without obsession, and work on global stress (relaxation, breaks, breathing, nature...).
👉 The complements, for Carole, are coming As a second intention, as an additional “layer” once the bases are adjusted.
Anti-oxidant and anti-inflammatory supplements
Carole cites several possible options, to be used in a targeted and accompanied manner:
- Phycocyanin (spirulina pigment):
- Interesting for its antioxidant effect, anti-inflammatory and immunomodulatory
- She considers it as very versatile, with a good tolerance profile, and often relevant in global prevention or support
- In practice: liquid form (bottle or ampules), average dosage around 60 mg/day, to be taken at the time that best suits the person
- Other more targeted molecules
- Astaxanthin: red pigment of marine origin, very antioxidant and anti-inflammatory, rather reserved for contexts where there is a real reason for using it.
- Pycnogenol (pine bark extract): antioxidant, anti-inflammatory, sometimes also used for pain.
- N-acetyl-cysteine (NAC): helps to regenerate glutathione, one of the body's main anti-oxidants; the need is ideally verified via an oxidative stress assessment before supplementing.
These supplements are chosen according to the context and the results of the assessment, not “at random” because we saw a post on the networks
⚠️ They never replace medical support when there is an inflammatory, autoimmune disease or ongoing care pathway
Microbiota and inflammation
Carole calls back The key role of microbiota (intestine, vagina, mouth...) in the regulation of immunity and inflammation.
When the populations of microorganisms are unbalanced (dysbiosis), this can maintain an inflammatory terrain that also affects fertility.
It gives some possible warning signals:
- Recurrent cystitis or mycosis
- Chronic digestive disorders, bloating, pain, very disturbed transit
- Allergies, food intolerances, specific reactions to certain foods
- Nidation or implantation problems (in PMA or not)
- Chronic oral problems (recurrent cavities, gingivitis, periodontitis, gum bleeding)
Two concrete axes:
- On the plate every day : fermented foods and drinks (sauerkraut, kimchi, lacto-fermented vegetables, lacto-fermented vegetables, sourdough bread, yogurts, kefir, kombucha, unfiltered/unpasteurized apple cider vinegar...).
- Targeted supplements : probiotics chosen according to the problem (for example repeated cystitis, digestive disorders...) with the help of a professional (pharmacist, doctor, other). Cures are generally limited in time, except in special cases.
🔎 Useful definitions
Free radicals : very reactive molecules produced by cellular metabolism or external factors (tobacco, pollution, UV...), capable of extracting electrons from lipids, proteins and DNA, which triggers oxidative stress when they are not sufficiently neutralized.
______
highly sensitive CRP (CRP-us) : blood assay of C-reactive protein with a very sensitive method, making it possible to detect low-grade chronic inflammation, even in the absence of acute illness, and to assess its potential impact on fertility and the chances of pregnancy.
🎯 Actions concrètes
- I'm asking myself if I am exposed to a lot of oxidative stress (tobacco, pollution, intense stress, very few fruits and vegetables, lack of sleep) and where I can start adjusting
- If that's the case, I start by trying to limit a source of oxidative stress : for example, stop the screens at night to sleep better or to reduce or stop smoking.
- If I have a known inflammatory or autoimmune disease, or chronic symptoms, I talk to my doctor to see if an ultrasensitive CRP or a more thorough assessment makes sense.
- I can introduce fermented foods gradually (sauerkraut, kimchi, kefir, kombucha, kombucha, yogurt, sourdough bread...) in my diet, starting with small amounts once a week.
- If I have recurrent cystitis, fungal infections, digestive disorders or oral problems,I ask a health professional if working on microbiota and targeted probiotics is relevant.
- If I want to test phycocyanin,I make sure that it is compatible with my health condition and my treatments, then I can consider taking around 60 mg/day, in addition to a healthy lifestyle that has already been worked on and over a period of 3 months to see the impact.
- I keep in mind that for my fertility and the quality of my oocytes, the goal is not to do “all the supplements”, but to reduce the background fire as much as possible (stress, inflammation, tobacco, pollution) and to support my body with the right tools, at the right time.
🔊 This program is an information program by a trained professional. This is generic advice and is not a personalized diagnosis. In all cases, we recommend that you be followed by a gynecologist and/or a midwife for individualized follow-up.
What you will learn in this episode
Oxidative stress and inflammation: what you need to know to manage them
- What is oxidative stress and the difference between oxidation and anti-oxidants
- How pollution, tobacco, stress, food... maintain chronic low-grade inflammation
- How oxidative stress and inflammation can damage cells, hormones, and oocyte quality
- What tests can explore inflammation and oxidative stress (highly sensitive CRP, specialized tests)
- Concrete daily levers: diet, lifestyle, targeted supplements, microbiota
Oxidative stress: what are we talking about?
Carole compares oxidative stress to a rusty nail: in the body, it is an imbalance between the production of free radicals and our anti-oxidant defenses.
A certain level of free radicals is normal and useful, but when they are produced in excess (tobacco, pollution, stress, poor diet...), they attack the lipids and proteins in our cells and end up damaging them.
- Ce oxidative stress ultimately promotes chronic low-grade inflammation, that stays “on” all the time instead of being punctual;
- In the field of fertility, it is associated with poorer oocyte quality, to more damage to the follicle and to poorer fertilization rates.
💡 Key figures
According to a study carried out in Denmark by the Fertily Department, women with mild chronic inflammation have approximately 10 to 20% less chance that the treatment works compared to those who don't.
Chronic inflammation: who is affected?
Carole recalls that you can sometimes “feel” that something is wrong, without it being measurable right away, but some situations are clearly at risk:
- Chronic inflammatory diseases (Crohn's disease, ulcerative colitis, rheumatoid arthritis, autoimmune diseases...)
- Persistent infections or viruses, lingering inflammations, pain or chronic symptoms
- And in a quieter way, low-grade inflammation linked to lifestyle (overweight, sedentary lifestyle, ultra-processed food, chronic stress...)
To objectify it:
- La Highly sensitive CRP is a simple test that makes it possible to assess a discreet inflammation and to monitor the effect of the actions implemented over time.
- For the oxidative stress, there are more comprehensive assessments, often in the form of non-reimbursed “packs”, which look at both the level of free radicals and certain key nutrients (for example selenium, which is also important for the thyroid).
Carole specifies that we do not do these assessments “to scare yourself” on a person in good shape without any particular problems: they are especially useful when there is a known inflammatory terrain or a baby project that is not progressing despite an initial assessment already well explored.
Act on the basics first: lifestyle
Before talking about complements, Carole comes back to the foundations:
- Limiting what feeds oxidative stress: tobacco, pollution, excess alcohol, lack of sleep, diet low in vegetables and fruits.
- Increase the natural intake of anti-oxidants via the plate: various vegetables, fruits, good oils, oilseeds, spices, etc.
- Move regularly, without obsession, and work on global stress (relaxation, breaks, breathing, nature...).
👉 The complements, for Carole, are coming As a second intention, as an additional “layer” once the bases are adjusted.
Anti-oxidant and anti-inflammatory supplements
Carole cites several possible options, to be used in a targeted and accompanied manner:
- Phycocyanin (spirulina pigment):
- Interesting for its antioxidant effect, anti-inflammatory and immunomodulatory
- She considers it as very versatile, with a good tolerance profile, and often relevant in global prevention or support
- In practice: liquid form (bottle or ampules), average dosage around 60 mg/day, to be taken at the time that best suits the person
- Other more targeted molecules
- Astaxanthin: red pigment of marine origin, very antioxidant and anti-inflammatory, rather reserved for contexts where there is a real reason for using it.
- Pycnogenol (pine bark extract): antioxidant, anti-inflammatory, sometimes also used for pain.
- N-acetyl-cysteine (NAC): helps to regenerate glutathione, one of the body's main anti-oxidants; the need is ideally verified via an oxidative stress assessment before supplementing.
These supplements are chosen according to the context and the results of the assessment, not “at random” because we saw a post on the networks
⚠️ They never replace medical support when there is an inflammatory, autoimmune disease or ongoing care pathway
Microbiota and inflammation
Carole calls back The key role of microbiota (intestine, vagina, mouth...) in the regulation of immunity and inflammation.
When the populations of microorganisms are unbalanced (dysbiosis), this can maintain an inflammatory terrain that also affects fertility.
It gives some possible warning signals:
- Recurrent cystitis or mycosis
- Chronic digestive disorders, bloating, pain, very disturbed transit
- Allergies, food intolerances, specific reactions to certain foods
- Nidation or implantation problems (in PMA or not)
- Chronic oral problems (recurrent cavities, gingivitis, periodontitis, gum bleeding)
Two concrete axes:
- On the plate every day : fermented foods and drinks (sauerkraut, kimchi, lacto-fermented vegetables, lacto-fermented vegetables, sourdough bread, yogurts, kefir, kombucha, unfiltered/unpasteurized apple cider vinegar...).
- Targeted supplements : probiotics chosen according to the problem (for example repeated cystitis, digestive disorders...) with the help of a professional (pharmacist, doctor, other). Cures are generally limited in time, except in special cases.
🎯 Concrete actions
- I'm asking myself if I am exposed to a lot of oxidative stress (tobacco, pollution, intense stress, very few fruits and vegetables, lack of sleep) and where I can start adjusting
- If that's the case, I start by trying to limit a source of oxidative stress : for example, stop the screens at night to sleep better or to reduce or stop smoking.
- If I have a known inflammatory or autoimmune disease, or chronic symptoms, I talk to my doctor to see if an ultrasensitive CRP or a more thorough assessment makes sense.
- I can introduce fermented foods gradually (sauerkraut, kimchi, kefir, kombucha, kombucha, yogurt, sourdough bread...) in my diet, starting with small amounts once a week.
- If I have recurrent cystitis, fungal infections, digestive disorders or oral problems,I ask a health professional if working on microbiota and targeted probiotics is relevant.
- If I want to test phycocyanin,I make sure that it is compatible with my health condition and my treatments, then I can consider taking around 60 mg/day, in addition to a healthy lifestyle that has already been worked on and over a period of 3 months to see the impact.
- I keep in mind that for my fertility and the quality of my oocytes, the goal is not to do “all the supplements”, but to reduce the background fire as much as possible (stress, inflammation, tobacco, pollution) and to support my body with the right tools, at the right time.
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